Demi Moore gives a career-best performance as Elisabeth Sparkle, a former A-lister past her prime and drawn to the opportunity presented by a mysterious new drug. All it takes is one injection and she is reborn – temporarily – as the gorgeous, twentysomething Sue (Margaret Qualley).

The only rule? Time needs to be split: exactly one week in one body, then one week in the other. No exceptions. Easy, right?

Deliriously entertaining and ruthlessly satirical, this explosive Cannes sensation from Coralie Forgeat (Revenge) is a be-careful-what-you-wish-for fable for the ages.


The Substance is nominated for five Academy Awards: Best Picture, Best Director, Best Actress, Best Original Screenplay, and Best Makeup and Hairstyling.